Asthma
Conditions
Interventions
None listed
Sponsors
Universiteit Utrecht
Eligibility
Age
2 Years to 17 Years
Inclusion criteria
Inclusion criteria: - Use R03 drugs - Age between 4-12 years - Parents able to speak, read and write Dutch language - At least 2 years of medication history available in which the child filled >=1 prescriptions for any asthma drug (RO3) within the last 6 months and at least 2 prescriptions in the last 12-24 months;For PACMAN phase 2 we will select a subgroup of these patients; - parents consented to be approached for future research - child is 8 years or older - child is adherent to ICS - child is classified as a non-responder (case) or responder to asthma medication (control)
Exclusion criteria
Exclusion criteria: - child is younger than 8 years - child does not use ICS - child is not adherent to ICS - consent is not obtained to be approached for future research during phase 1
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Study outcome: - treatment response. - biomarkers for therapy response Study parameters: - genetic polymorphisms (SNPs) - patient characteristics (other than genetic factors) We will focus on SNPs in genes involved in pharmacological asthma treatment pathways. To measure the treatment response and to make correctuin for confounders the parents are asked to fill in a questionnaire on symptoms, medication use, environmental factors etc. In addition we will assess whether we can measure the gut microbiome in children who remain uncontrolled despite treatment in a pilot study setting. | — |
Countries
Netherlands
Outcome results
None listed