Facial and hand analysis, sleep apnea and speech in patients with acromegaly: a prospective study to investigate changes in craniofacial and hand characteristics, sleep apnea and speech during treatment and after remission.

Facial and hand analysis, sleep apnea and speech in patients with acromegaly: a prospective study to investigate changes in craniofacial and hand characteristics, sleep apnea and speech during treatment and after remission. - Prospective study on changes in acromegaly

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON41364

Enrollment

Registered

2012-05-24

Start date

2012-10-11

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Growth hormone excess

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Newly diagnosed acromegaly - Diagnosis is biochemically confirmed by an increased IGF-1 level (mean +2 standard deviations for age) and insufficient suppression of serum GH levels (e.g. GH levels >= 2mU/l) during oral glucose tolerance test. - Subjects should be over 18 years old with the ability to read and comprehend the Dutch language

Exclusion criteria

Exclusion criteria: - Pregnancy - Maxillofacial surgical treatment in the past. - Hand surgery in the past - Speech pathology unrelated to acromegaly

Design outcomes

Primary

Measure	Time frame
Parameters of facial analysis with 3D stereophotography and cone beam CT and hand analysis with 3D stereophotography respectively, biochemical parameters of disease activity, disease related and general QOL using the AcroQol and RAND-36 questionnaires, speech analysis and the voice handicap index questionnaire and severity of sleep apnea using complete overnight polysomnography and the Epworth sleepiness scale questionnaire.	—

Measure

Time frame

Parameters of facial analysis with 3D stereophotography and cone beam CT and hand analysis with 3D stereophotography respectively, biochemical parameters of disease activity, disease related and general QOL using the AcroQol and RAND-36 questionnaires, speech analysis and the voice handicap index questionnaire and severity of sleep apnea using complete overnight polysomnography and the Epworth sleepiness scale questionnaire.

—

Secondary

Measure	Time frame
In vitro inflammatory cytokineproduction and foam cell formation of monocytes obtained from patiënts with acromegaly	—

Countries

Netherlands

Outcome results