neonatal stroke
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
2 Years to 17 Years
Inclusion criteria
Inclusion criteria: A) preterm infants with a gestational age =37 weeks gestation admitted to our level III neonatal intensive care unit with 1) neonatal encephalopathy and/or seizures and diagnosed to have PAIS which subsequently did or did not result in hemiplegic cerebral palsy, and (2) an MRI during the neonatal period and often also at 24 months of age. Starting from the first of january 2011 we will also include children with CP due to a PAIS who were referred to the VU medical centre in Amsterdam. They will be studied in the UMCU. Furthermore we will continue including children who fulfill the inclusion criteria as mentioned earlier, but also included children at the age of six years and older. In 2015, an additional five patients will be included. These patients were previously too young to be included, but have now reached the age of six years or older.
Exclusion criteria
Exclusion criteria: Preterm infants with lesions affecting both hemispheres, like periventricular leukomalacia. Fullterm infants with lesions affecting both hemispheres, such as injury to the central grey nuclei or watershed injury, occurring in infants with hypoxic-ischemic encephalopathy Infants with congenital anomalies, chromosomal disorders, or infections of the central nervous system are also not eligible for the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Outcome measures Primary outcome measure: nature of reorganisation, defined as *intra- hemispheric reorganisation* or *inter-hemispheric reorganisation* and relation between reorganisation and *functional outcome*, assessed with gross- and fine motor developmental status (see methods). | — |
Countries
Netherlands
Outcome results
None listed