herniated disc Lumbar disc herniation
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Patients - Patients suffering from lumbar disc herniation - Symptoms associated with sciatica coming from compressed disfunctional nerves at the level of L3 - S1 - Patients
Exclusion criteria
Exclusion criteria: Patients - Patients with pervious history of spinal trauma, surgery or neurological disease - Patients with previous history of malignancies - Patients with previous radicular syndrom - Patients with other back problems - Patients with a contraindication to MRI (i.e. pacemaker);Healthy subjects - Volunteers with a contraindication to MRI (i.e. pacemaker) - Volunteers who do not want to be informed about potential findings related to their health
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The apparent diffusion coefficient (ADC), fractionele anisotropie (FA), axiale diffusiviteit (AD), and radiale diffusiviteit (RD) will be measured. The program ExploreDTI (©: Alexander Leemans) will be used to visualize these nerves. With this it will be examined whether it is possible to characterize the diffusion of the molecules in the nerve tissue. The ADC, FA, AD, and RD will be measured in the DTI images using the program ExploreDTI of Alexander Leemans, working in the UMCU at the Image Science Institute (ISI). The hypothesis is that the diffusion parameters of the affected nerve root on the level of the lumbar disc herniation will differ from the contralateral nerve root. This will be verified by comparing them to nerve roots in healthy volunteers. This will also indicate whether or not the herniated disc will affect the diffusion parameters and anatomy of other nerve roots in the patient. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secundary research variable is the anatomy and functionality on the level of the lumbar disc herniation and the nerve roots in comparison to the healthy contralateral side. To be able to answer this the research question we would like to visualize the anatomy and organisation of the nerves of this group of patients, where we want to compare the affected nerves and the healthy nerves qualitatively. Our hypothesis is that the nerves on the level of the lumbar disc herniation will be disturbed. To identify whether or not the hernia does not affect other nerve roots in the patients the results will be compared to the nerve root organisation of healthy volunteers. In case this correlation is identified the information of healthy volunteers will also be used to indicate in what way the hernia affect other nerve roots. | — |
Countries
Netherlands
Outcome results
None listed