Migraine
Conditions
Interventions
None listed
Sponsors
Leids Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria are: i) migraine with/ without aura according to the IHS criteria; ii) baseline attack frequency of 1 to 3 attacks per month; iii) moderate or severe headache during attacks; iv) age>18 years; v) residential or working in the Heemstede region or SEIN.
Exclusion criteria
Exclusion criteria: Exclusion criteria are: i) more than 10 days of headache per month; ii) inability to differentiate between migraine and other forms of headache; iii) suffering from another neurologic or psychiatric disease; iv) structural inabililty to stay supine without major movements (e.g. restless legs syndrome, tremor etc.); v) excessive sweating (may influence conduction between skin and electrodes); vii) use of neurologic or psychiatric medication that could affect cortical functioning.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Outcome measures Large unilateral DC-potential shifts indicative of a spreading depression during the onset and duration of a reported aura phase in MA patients, or during the initiation of a headache phase in MO patients, comparing data from the two hemispheres. Analyses will be adjusted for end-tidal pCO2 levels. | — |
Secondary
| Measure | Time frame |
|---|---|
| TMS: Motor threshold and stimulus response curves during the different phases of migraine headache. | — |
Countries
Netherlands
Outcome results
None listed