Local and systemic antibody responses for maintaining gingival health

Local and systemic antibody responses for maintaining gingival health - Antibodies for periodontal health

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON41332

Enrollment

Registered

2013-07-11

Start date

2013-12-09

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

gum inflammation periodontitis

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: * >18 and

Exclusion criteria

Exclusion criteria: * 60 years of age * Used antibiotics in the last 3 months * People receiving immunosuppressive therapy or taking other immunomodulating agents * Having received periodontal treatment

Design outcomes

Primary

Measure	Time frame
From each patient, the relative frequencies of B- and T-cell subsets will be determined, both in tissue and blood. These parameters will be compared between patients and controls. Additionally, immunohistochemical analysis of paraffin embedded biopsies will be performed to assess overall morphology and cell types present. Finally, antibodies will be cloned from single sorted plasma cells, and these will be tested for their (auto-) reactivity. This will all be related to the bacterial composition in periodontitis.	—

Measure

Time frame

From each patient, the relative frequencies of B- and T-cell subsets will be determined, both in tissue and blood. These parameters will be compared between patients and controls. Additionally, immunohistochemical analysis of paraffin embedded biopsies will be performed to assess overall morphology and cell types present. Finally, antibodies will be cloned from single sorted plasma cells, and these will be tested for their (auto-) reactivity. This will all be related to the bacterial composition in periodontitis.

—

Secondary

Measure	Time frame
nvt	—

Countries

Netherlands

Outcome results