atrial fibrillation cardiac arrhythmia
Conditions
Interventions
The 3 groups undergo cryoballoon ablation with the new balloon, with a duration
of cryoenergy application of 90, 120 or 150 seconds after PVI.
Sponsors
Leids Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Any patient with atrial fibrillation scheduled for a first ablation procedure
Exclusion criteria
Exclusion criteria: Previous catheter or surgical ablation for atrial fibrillation, (longstanding) persistent atrial fibrillation, a diameter of one or more pulmonary veins > 28 mm and > 3 veins on the right side
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of dormant conduction during the ablation procedure will be established en compared for three different ablation timeframes including 90, 120 or 150 seconds of additional cryoballoon ablation after acute PV isolation | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. The efficacy of AF ablation with the second-generation cryoballoon at 1 year follow-up will be investigated and also compared for the three different ablation timeframes 2. The incidence of (transient) phrenic nerve injury for the three groups will be registered and compared. The influence of the distance measured on CT scan between the RSPV ostium and the right phrenic nerve on the incidence will be assessed. 3. The incidence of esophageal lesions for the three groups will be established with gastroendoscopy and compared. The influence of minimal luminal esophageal temperature (LET) and cryoballoon temperature, duration of cryoenergy application and mean LET decrease on the formation of thermal lesions will be evaluated. | — |
Countries
Netherlands
Outcome results
None listed