Hemodynamic adaptation of the right ventricle in monochorionic twin pregnancies complicated by twin-to-twin transfusion syndrome or selective growth restriction

Hemodynamic adaptation of the right ventricle in monochorionic twin pregnancies complicated by twin-to-twin transfusion syndrome or selective growth restriction - HEARTTS

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON41328

Enrollment

220

Registered

2015-03-02

Start date

2015-04-01

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

heart failure pulmonary stenosis

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: * All women pregnant of monochorionic twins * Ability to give informed consent

Exclusion criteria

Exclusion criteria: * Fetuses with non-cardiac congenital anomalies * Fetuses with chromosomal abnormalities * Maternal age

Design outcomes

Primary

Measure	Time frame
The size and growthpattern of the pulmonary artery at the level of the valve, expressed in standard deviations from the mean (according to Shapiro et al.28).	—

Secondary

Measure	Time frame
1. The growth curve of the pulmonary artery, the maximum velocity (Vmax) curve of the pulmonary artery and veins in - TTTS or sIUGR with development of RVOTO . - TTTS or sIUGR without development of RVOTO. - Twins of uncomplicated MCDA pregnancies 2. The MPI and Tissue Doppler of the myocard of the right ventricle in fetusses in complicated monochorionic twin pregnancies, compared with fetusses in uncomplicated monochorionic twin pregnancies.	—

Measure

Time frame

1. The growth curve of the pulmonary artery, the maximum velocity (Vmax) curve of the pulmonary artery and veins in - TTTS or sIUGR with development of RVOTO . - TTTS or sIUGR without development of RVOTO. - Twins of uncomplicated MCDA pregnancies 2. The MPI and Tissue Doppler of the myocard of the right ventricle in fetusses in complicated monochorionic twin pregnancies, compared with fetusses in uncomplicated monochorionic twin pregnancies.

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Countries

Netherlands

Outcome results