Parkinson's disease
Conditions
Interventions
1. Tryptophan depletion vs placebo condition (= no depletion)
2. In both conditions patients will be tested with their DBS stimulator on and
off
Sponsors
Medisch Universitair Ziekenhuis Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Subjects must be mentally competent (*wilsbekwaam*) Subjects must have undergone STN DBS surgery for Parkinson's disease symptomatology ;Age, duration and severity of disease, duration of DBS implantation do not play a role in the selection process.
Exclusion criteria
Exclusion criteria: Head injury Stroke Neurological disorders other than PD Psychoactive medication: antidepressants and antipsychotics (a stable dose of benzodiazepines will be allowed). Clinically relevant cognitive decline, operationalized as an Mini Mental State Examination score 16 or a score >2 on any of the MDS-UPDRS section I items. Current malignancy or infection;Age, duration and severity of disease, duration of DBS implantation do not play a role in the selection process.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Our primary outcome measures are changes in mood scales (depression, (hypo)mania). | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcome measures are 1) the motor scores as assessed through the Unified Parkinson Disease Rating Scale and the motor component of the reaction time task; 2) impulsivity as assessed through the impulsivity component of the reaction time task. 3) emotional responsiveness as assessed through the emotional responsiveness task. | — |
Countries
Netherlands
Outcome results
None listed