reproductive technology unexplained subfertility
Conditions
Interventions
A maximum of 4 cycles of IUI with ovarian stimulation with either FSH or CC in
a time horizon of 6 months.
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Couples diagnosed with unexplained subfertility or mild male factor;Unexplained subfertility is defined as: 12 month unprotected regular intercourse male partner had normal or mild impairment of semen quality with total motile sperm count above 10 millon female partner has a regular menstrual cycle, at least one sided tubal patency Poor prognosis for natural conception according to model of Hunault (dutch guidelines) in order to justify start of treatment with IUI
Exclusion criteria
Exclusion criteria: - double sided tubal pathology - impaired semen quality - women with irregular cycle - age below 18 and above 42
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ongoing pregnancy rate | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Number of cycles with monofollicular growth 2. Number of cycles with multiple follicle growth 3. Number of cancelled cycles due to the occurrence of >3 follicles >15 mm 4. Difference in severity of known adverse effects 5. Time to ongoing pregnancy rate 6. Clinical pregnancy 7. Miscarriage rate 8. Live birth rate 9. Multiple pregnancies 10. Patients preference by DCE 11. Direct and indirect costs | — |
Countries
Netherlands
Outcome results
None listed