The cardiac contribution to cerebral perfusion - 'the heart-brain axis'

The cardiac contribution to cerebral perfusion - 'the heart-brain axis' - Cardiac contribution to cerebral perfusion

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON41298

Enrollment

Registered

2013-05-28

Start date

2013-06-06

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

circulation

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: * Age between 18 to 30 years (younger subjects), age between 50 to 60 years (older subjects) or age 75 years and older (old subjects)

Exclusion criteria

Exclusion criteria: * Frail elderly (presence of *3 criteria: weight loss, weakness, poor endurance/exhaustion, slowness, low physical activity) * Medical history of CV disease, hypertension, diabetes mellitus, pulmonary disease, neurological disease, malignant disease and/or venous insufficiency * Abnormal lab results (medical screening) * Stenosis of (one of) the carotid arteries (retrospectively) * Abnormal ECG (medical screening) * Use of systemic medication * Any cognitive impairment (MMSE>24 points) * Contraindication to MRI exposure

Design outcomes

Primary

Measure	Time frame
The primary end-points of this study are systemic blood flow and cerebral perfusion.	—

Secondary

Measure	Time frame
- Blood pressure - Cardiac output - Age - Cerebrovascular reactivity	—

Countries

Netherlands

Outcome results