Hunger Winter Generations Study (The HWG Study)

Hunger Winter Generations Study (The HWG Study) - HWG study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON41296

Enrollment

500

Registered

2015-02-10

Start date

2015-01-15

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Malnutrition during pregnancy

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Preferably families will be included where the exposed F1 (F1e) and the non-exposed sibling (F1c) together with two of their offspring (F2e, F2c), i.e. four subjects in one family (F1e, F1c, F2e, F2c) agree to participate. However, incomplete families will be included as well.

Exclusion criteria

Exclusion criteria: We will exclude control individuals if they were born between November 1944 and March 1946 and lived in a town that was known to be affected by the Dutch Famine.

Design outcomes

Primary

Measure	Time frame
To investigate whether the differences in DNA methylation between individuals who were exposed in utero to the Dutch Hungerwinter and their non-exposed, siblings as identified in epigenome-wide studies are transmitted to a second generation.	—

Secondary

Measure	Time frame
Secondary endpoint of this study is the measurement of genetic variation. DNA methylation differences within and between generations may be driven or confounded by genetic variation.	—

Countries

Netherlands

Outcome results