Contrast-enhanced MR imaging of ductal carcinoma in-situ/invasive lobular carcinoma in supine position: a pilot study

Contrast-enhanced MR imaging of ductal carcinoma in-situ/invasive lobular carcinoma in supine position: a pilot study - Supine contrast enhanced MRI of DCIS/ILC

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON41290

Enrollment

Registered

2013-12-18

Start date

2014-01-01

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Borst diagnostisch verrichting ductal carcinoma in-situ/invasive lobular carcinoma Early stage breast cancer

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Histological proven invasive breast cancer with a DCIS (component) or pure ILC Schedule for breast conserving therapy A diagnositic contrast enhance MRI in prone position Informed consent >

Exclusion criteria

Exclusion criteria: Contra indication for MRI Contra indication for gadolinium contrast administration

Design outcomes

Primary

Measure	Time frame
The primary goal, diagnostic quality of supine CE-MRI, will be evaluated by 4 radiologists. Each will compare the diagnostic quality with the prone CE-MRI in terms of supine is: better, equal or worse. The image quality of the supine scan will visually be judged on visibility of the lesion extent, in categories, excellent, reasonable, dubious, and impossible.	—

Secondary

Measure	Time frame
The secondary parameter is the accuracy of deformable image registration between prone CE-MRI scans and supine non-CE-MRI scans. Registration accuracy will be assessed by defining a set of corresponding anatomical landmarks in both images before registration. After registration, the distance between corresponding anatomical landmarks defines the registration accuracy. The identification of landmarks will be performed by two radiologists. The first radiologist will define the landmarks on both the prone and the supine scan. The second radiologist will be provided with the landmarks of the other radiologist on the prone scan, and define the corresponding landmarks on the supine scan. An ANOVA method will be used to define registration accuracy, taking into account observer variation.	—

Measure

Time frame

The secondary parameter is the accuracy of deformable image registration between prone CE-MRI scans and supine non-CE-MRI scans. Registration accuracy will be assessed by defining a set of corresponding anatomical landmarks in both images before registration. After registration, the distance between corresponding anatomical landmarks defines the registration accuracy. The identification of landmarks will be performed by two radiologists. The first radiologist will define the landmarks on both the prone and the supine scan. The second radiologist will be provided with the landmarks of the other radiologist on the prone scan, and define the corresponding landmarks on the supine scan. An ANOVA method will be used to define registration accuracy, taking into account observer variation.

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Countries

Netherlands

Outcome results