Stimulation of the autonomic nervous system in colorectal surgery by perioperative nutrition

Stimulation of the autonomic nervous system in colorectal surgery by perioperative nutrition - Perioperative nutrition in colorectal surgery

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON41286

Enrollment

280

Registered

2013-11-15

Start date

2014-07-28

Completion date

Unknown

Last updated

2025-03-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

lekkage van de darmaansluiting verlamming van de darm

Interventions

Perioperative nutrition via a nasojejunal tube

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - patients that undergo colorectal surgery with primary anastomosis - written informed consent - age above 18 years

Exclusion criteria

Exclusion criteria: - use of medication that disrupts acetylcholine metabolism - steroid use - previous gastric or esophageal resection - peritoneal metastases found during surgery - pre-existent or creation of an ileostomy

Design outcomes

Primary

Measure	Time frame
Main clinical outcome parameter is postoperative ileus.	—

Secondary

Measure	Time frame
- Anastomotic leakage - Aspiration pneumonia - Gastric volumes preoperatively - Length of functional recovery - The local and systemic inflammatory response - Surgical complications - Length of stay - Intestinal barrier function and local inflammation in the gut - Need for additional surgical, radiological or endoscopic interventions - Need for ICU admission and total length of ICU stay - micriobiota in feces pre and postoperatively - Quality of life (EQ-5D and EORTC-QLQ-C30 at baseline, after 3 and 6 months)	—

Measure

Time frame

- Anastomotic leakage - Aspiration pneumonia - Gastric volumes preoperatively - Length of functional recovery - The local and systemic inflammatory response - Surgical complications - Length of stay - Intestinal barrier function and local inflammation in the gut - Need for additional surgical, radiological or endoscopic interventions - Need for ICU admission and total length of ICU stay - micriobiota in feces pre and postoperatively - Quality of life (EQ-5D and EORTC-QLQ-C30 at baseline, after 3 and 6 months)

—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)