The effect of a combined caloric restriction and exercise intervention on phenotypic profiles of offspring of families with exceptional longevity and their partners

The effect of a combined caloric restriction and exercise intervention on phenotypic profiles of offspring of families with exceptional longevity and their partners - Growing Old Together

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON41285

Enrollment

194

Registered

2012-02-06

Start date

2012-03-20

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

lichaamsgewicht, lichaamssamenstelling, bloeddruk, metabole markers gerelateerd aan glucose- en vetstofwisseling body composition energy metabolism fat metabolism glucose metabolisme

Interventions

3 months (13 weeks) intervention with 25% lowered energy expenditure by 12.5% caloric restriction and a 12.5% increase in physical activity.

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Main study: • Middle-aged (=23 and = 60 and =23 and

Exclusion criteria

Exclusion criteria: Main study: • Type I or type II diabetes (on diabetic medication) • Individuals who have lost or gained >=3 kg over the past 6 months • Individuals engaged in heavy/intensive physical activity (top sport or physically heavy work) • Any disease or condition that seriously affects body weight and/or body composition including active types of cancer, heart failure (NYHA III/VI), COPD (GOLD III/VI) • Recent (3 months prior to intervention) immobilisation for longer than 1 week • Psychiatric or behavioral problems (eg, history or clinical manifestation of any eating disorders, vegan dietary lifestyle, major depression) • Medication: thyroid medication, immunosuppressive drugs (e.g. prednisone, methotrexat, biologicals (TNF-alpha antagonists etc)) use of anticoagulantia (e.g. coumarines, carbaspirin calcium): only excluded for biopsies • Concurrent participation in any other intervention study or weight management program;Magnetic Resonance (MR) exclusion criteria (3 tesla and 7 tesla): • Claustrophobia • Pacemakers and defibrillators • Nerve stimulators • Intracranial clips • Intraorbital or intraocular metallic fragments • Cochlear implants • Ferromagnetic implants (e.g. thoracic implant for scoliosis) • Inability to lie supine during for 1 hour • not having a general practitioner;Validation study: • Any conditions that may inhibit free movement • Individuals engaged in heavy/intensive physical activity (top sport or physically heavy work)

Design outcomes

Primary

Measure	Time frame
Primary outcome measure is the change in fasting insulin level.	—

Secondary

Measure	Time frame
Secondary outcome measures are blood parameters (metabolic/metabolomics), parameters measured in biopsies of muscle and fat (proteomics/epigenetics), anthropometrics, body composition, blood pressure, 24-hour glucose monitoring, glucose load, energy metabolism (resting metabolic rate), and psychological factors (cognitive performance, mood, quality of life, sleep, hunger) parameters Magnetic Resonance (MR) scan (leg, brain, knee cartilage) and activity levels.	—

Measure

Time frame

Secondary outcome measures are blood parameters (metabolic/metabolomics), parameters measured in biopsies of muscle and fat (proteomics/epigenetics), anthropometrics, body composition, blood pressure, 24-hour glucose monitoring, glucose load, energy metabolism (resting metabolic rate), and psychological factors (cognitive performance, mood, quality of life, sleep, hunger) parameters Magnetic Resonance (MR) scan (leg, brain, knee cartilage) and activity levels.

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Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)