KIRS-study: expression of inhibitory receptors on polymorphonuclear neutrophils during sepsis in children

KIRS-study: expression of inhibitory receptors on polymorphonuclear neutrophils during sepsis in children - KIRS

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON41281

Enrollment

Registered

2013-03-19

Start date

2013-09-23

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Blood poisoning Sepsis

Interventions

None listed

Eligibility

Age

2 Years to 11 Years

Inclusion criteria

Inclusion criteria: Sepsis patients: under age 12, diagnosed with severe paediatric sepsis or paediatric septic shock Control group 1: patients under age 12, admitted to the ICU for a non-infectious, non-inflammatory illness Control group 2: patients under age 12, undergoing elective cardiac catheterization.

Exclusion criteria

Exclusion criteria: Patients with any type of chronic infectious, inflammatory or autoimmune diseases Patients after hematopoietic or solid organ transplantation Patients receiving long term treatment with steroids or other immunosuppressive agents Patients with an immunodeficiency For control group 2: cyanotic heart disease

Design outcomes

Primary

Measure	Time frame
Inhibitory receptor (SIRL-1 and LAIR-1)expression on blood neutrophils Disease severity as determined by the PRISM-III score, PELOD-2 score and Inotropic score	—

Secondary

Measure	Time frame
none	—

Countries

Netherlands

Outcome results