Feasibility test of a respiratory challenge in the MRI to image the vascularity of the brain and the head and neck area.

Feasibility test of a respiratory challenge in the MRI to image the vascularity of the brain and the head and neck area. - MRI with RespirAct

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON41270

Enrollment

145

Registered

2013-04-09

Start date

2013-07-04

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

head and neck cancer Vascular disease of the brain

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Informed consent - 18 years or older

Exclusion criteria

Exclusion criteria: - Unwilling or unable to co-operate with breathing manoeuvres - Respiratory or cardiac limitations to breathing at 20 L/min - Medical contra-indications to limited hypercapnia or hypocapnia (known increased intracerebral pressure, metabolic acidosis or alkalosis) - Brain or head and neck tumour - Vascular disease of the brain - Altered consciousness - Standard contraindications for 3T or 7T MRI scanning - Non compliance with prescribed anti-seizure medication - Pregnancy

Design outcomes

Primary

Measure	Time frame
The primary study parameter is the feasibility of MRI measurements at 3T and 7T under dynamic hypercapnic or hyperoxic conditions.	—

Secondary

Measure	Time frame
Control values of vascular reactivity and oxygenation status in brain and head and neck region.	—

Countries

Netherlands

Outcome results