Neural Correlates of Apathy In Mild Cognitive Impairment (MCI)

Neural Correlates of Apathy In Mild Cognitive Impairment (MCI) - Apathy and Memory

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON41265

Enrollment

Registered

2013-01-25

Start date

2013-04-22

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

apathy dementia

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: All subjects: - Age from 60yrs to 80yrs - Willingness to cooperate and sign written informed consent;Normal Healthy Controls: - MMSE scores between 28 and 30;aMCI with apathy -Diagnosis of aMCI as assessed by clinician and neuropsychologist, according to Petersen 1999. -Apathy diagnosed by apathy criteria (Robert 2009), assessed by clinician and neuropsychologist ;aMCI without apathy -Diagnosis of aMCI as assessed by clinician and neuropsychologist, according to Petersen 1999 -Apathy excluded according to apathy criteria (Robert 2009), assessed by clinician and neuropsychologist

Exclusion criteria

Exclusion criteria: All subjects: -Medications which may affect the experimental outcomes -Existence of psychiatric conditions with exception of depression or neurological conditions or problems with eyesight -MR incompatible implants in the body (such as ear prosthesis, pacemakers, implanted heart valves etc). All subjects have to fill out a detailed questionnaire covering safety aspects of the research in relation to the 3 Tesla magnetic field and the MRI environment. -Any risk of having metal particles in the eyes due to manual work without proper eye protections -Tattoos containing red pigments that form a safety risk -Claustrophobia -The refusal to be informed of structural brain abnormalities that could be detected during the experiment ;Normal Heathy Controls: -Abnormal result on any neuropsychological test -Diagnosis of AD by NINCDS/ADRDA criteria (McKhann 1984) and DSM-IV criteria, assessed by clinician and neuropsychologist aMCI with apathy, aMCI without apathy -Diagnosis of AD by NINCDS/ADRDA criteria (McKhann 1984) and DSM-IV criteria, assessed by clinician and neuropsychologist

Design outcomes

Primary

Measure	Time frame
Functional MRI data will be analysed for areas of activation and functional connectivity between these areas while Diffusion Weighted Imaging will be used to study the structure of tracts. Metabolite abnormalities will be assessed using a Magnetic Resonance Spectroscopy scan.	—

Secondary

Measure	Time frame
n.a.	—

Countries

Netherlands

Outcome results