Evaluation of tumor variability with MRI before and during radiotherapy treatment in patients with an orpharyngeal or oral cavity carcinoma

Evaluation of tumor variability with MRI before and during radiotherapy treatment in patients with an orpharyngeal or oral cavity carcinoma - Repeat MRI study before and during radiotherapy

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON41260

Enrollment

Registered

2010-09-09

Start date

2011-01-10

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

oropharyngeal/oral cavity cancer throat cancer

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Histology proven squameus carcinoma of oropharynx or oral cavity - Bulky T2-4, Nx, M0 - Planned for curative radio-chemotherapy

Exclusion criteria

Exclusion criteria: Contra indication for MRI

Design outcomes

Primary

Measure	Time frame
Analyses: Rigid match of MRI and CT/CBCT: - Drawing of GTV volume on MRI and CT - Mapping of marker position on CT and daily CBCTs - Evaluation of volume changes preRT MRI compared to MRI in week 3 - Evaluation of marker position compared to MRI volume - Evaluation of daily marker position on CBCT - Comparing of organs at risk on CT, CBCT and MRI - Evaluation of interobserver variation of three delineators - Analysis of dosimetric consequences of volume changes during radiotherapy - Analysis of Ktrans en Vp of the 3 MRI scans performed before the start of treatment	—

Measure

Time frame

Analyses: Rigid match of MRI and CT/CBCT: - Drawing of GTV volume on MRI and CT - Mapping of marker position on CT and daily CBCTs - Evaluation of volume changes preRT MRI compared to MRI in week 3 - Evaluation of marker position compared to MRI volume - Evaluation of daily marker position on CBCT - Comparing of organs at risk on CT, CBCT and MRI - Evaluation of interobserver variation of three delineators - Analysis of dosimetric consequences of volume changes during radiotherapy - Analysis of Ktrans en Vp of the 3 MRI scans performed before the start of treatment

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Secondary

Measure	Time frame
Niet van toepassing	—

Countries

Netherlands

Outcome results