hartinfarct, herstel na behandeling van linker kamer remodelling of the left ventricle treatment of multivessel disease
Conditions
Interventions
After informed consent and immediately after the PPCI patients with multivessel
disease will be randomized to either early complete revascularization (CR
LV-remodeling
multivessel disease
STEMI
timing
Sponsors
HagaZiekenhuis
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: primary PCI, STEMI, multivessel disease, older than 18 years, hemodynamic stable
Exclusion criteria
Exclusion criteria: cardiogenic shock, resucitation, intra-aortic balloon pump, mechanical ventilation, prior infarction or CABG, life expectancy less than 2 years
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary aim of our study is to assess the association of timing of CR and left ventricular remodelling (increase in end diastolic volume [EDV]>20%) or an increase of at least 5% in left ventricular function after primary PCI in STEMI patients with multi-vessel disease. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary objective of our study is to assess the correlation of plasma serum BNP level within the first 24-96 hours of STEMI and the development of subsequent left ventricular dilatation according to CR-group at 3, 6 and 12 months of follow-up on imaging (serial MRI and/or echocardiography) and mortality (all cause and cardiac). | — |
Countries
The Netherlands
Outcome results
None listed