sleep loss sleep loss sleep quality
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: Healthy men and women between 18 and 45 years of age Chronotype (MSFsc) of greater than 4 (meaning a sleep mid point at 04:00 a.m.) Social jetlag = difference between mid-sleep on workdays and days off of minimum 2 hours Habitual sleep duration on free days between 6 and 10 hours Bed partners agree to the study protocol Written informed consent
Exclusion criteria
Exclusion criteria: Sleep disorders, e.g. sleep apnoea, narcolepsy, restless legs, primary insomnia Mood disorder; because of the possibility of depressive mood as co morbidity in late chronotypes we will set the criterion for exclusion based on depressive mood on a BDI-II rating equal to or higher than 16 (indicating severe dysphoric or depressed mood) Two or more time zones crossed 1 month before study participation Shift-work during 5 years prior to participation Recent eye surgery (last year), glaucoma or other eye disease History of chronic diseases, and/or use of chronic medication for 3 months or longer before study participation Alcohol or drug problems (based on answers to the General Questionnaire) The use of sleep and photosensitizing medication
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sleep timing and sleep quantity from sleep diaries (subjective) and actimetry (objective; sub-group only). | — |
Secondary
| Measure | Time frame |
|---|---|
| Sleep quality from subjective sleep diaries, and light exposure assessed from sleep diaries. In addition, secondary objective parameter in this study in a sub-sample of 20 participants is melatonin concentration in saliva. The start of the rhythm will be measured: dim light melatonin onset (DLMO). A shift in DLMO is interpreted as a shift in the endogenous circadian pacemaker. | — |
Countries
Netherlands