seksuele functie- en fertiliteitsstoornissen premature menopause Premature ovarian failure (POF)
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - POI patient - Being treated for POI - Aged 18 - 39 - Understanding of Dutch language - Able and willing to provide informed consent - In a relationship (>3 months) - Control groups should be using one of the following birth control methods: the second, third or fourth generation pill or Mirena intra uterine device
Exclusion criteria
Exclusion criteria: - Oophorectomy or radiation of the ovaries - Androgen therapy during the six months prior to study start - Lactation and/or pregnancy in the six months prior to study start - Subjects experiencing relational discord as indicated by a score of >= 20 on the MMQ-M - Other birth-control methods than described at inclusion criteria or no birth-control - Chronic disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Hormone determinations: - FSH - 17-ß estradiol - total testosterone - SHBG - Free testosterone (calculated with Free Androgen Index (FAI): [total testosterone] / [SHBG] x 100) - DHEA 2. Genital response measured as VPA during: - self-induced erotic fantasy - watching sexual stimuli (erotic film) - at baseline 3. Subjective genital response determined by questions about: - overall feeling of sexual arousal - strongest feeling of sexual arousal - strongest genital sensation - amount of vaginal lubrication 4. Implicit associations respective to sexual stimuli by measuring reaction times | — |
Secondary
| Measure | Time frame |
|---|---|
| Questionnaires: FSFI, FSDS-R, MMQ | — |
Countries
Netherlands
Outcome results
None listed