Influence of arterial bicarbonate level on respiration control in healthy subjects

Influence of arterial bicarbonate level on respiration control in healthy subjects - Bicarbonate and respiratory control

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON41176

Enrollment

Registered

2014-05-20

Start date

2014-12-01

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Regulatie ademhalingscentrum in het brein, chemosensitiviteit chemosensitivity Regulation of breathing centre in the brain

Interventions

The intervention consists of oral administration of sodium bicarbonate during 3 days 3 times a day and the fourth day a last dosis.

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Informed consent Age >18 year,

Exclusion criteria

Exclusion criteria: Pre-existent pulmonary problems Hypo- or hyperventilation syndrome Use of prescribed medication BMI>35 Upper airway/esophageal/mouth or face pathology

Design outcomes

Primary

Measure	Time frame
The main study parameter is the difference between ventilatory response with normal and increased bicarbonate level.	—

Secondary

Measure	Time frame
The second study parameter is the difference between electrical activity of the diaphragm muscle during the normal ventilatory response and after bicarbonate administration.	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)