Post-sternotomy mediastintis surgical site infection after cardiac surgery
Conditions
Interventions
Patients in the treatment group receive two collagenous drug carriers loaded
with gentamicin between the sternal halves before closure. Patients in the
control group are closed as usual.
Sponsors
Sint Antonius Ziekenhuis
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Age above 18 years - Underwent a cardiothoracic procedure through median sternotomy - Clinical signs of PSM as described by the Centres for Disease Control and Prevention (CDC)
Exclusion criteria
Exclusion criteria: - Patients with severe renal failure (serum creatinine above 150 µmol/L) - Patients with neuromuscular diseases - Patients who are allergic for aminoglycosides - Patients with systemic lupus erythematosus, scleroderma or chronic polyarthritis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hospital stay | — |
Secondary
| Measure | Time frame |
|---|---|
| In-hospital mortality Duration of wound sterilization Duration of antibiotic treatment Duration of drainage CRP decline Leukocyte decline | — |
Countries
Netherlands
Outcome results
None listed