slow vision slow visual processing speed
Conditions
Interventions
None listed
Sponsors
Radboudumc
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Between 18 and 65 years old - Visual acuity >= 0.6 - Normal birth weight (i.e. >= 2500 g) and pregnancy duration (i.e. >= 37 weeks);Patients: Probable slow vision: Complaints related to slow visual processing, for example: - Reading slowly - Being unable to read subtitles(e.g. during movies) in time (i.e. before they disappear from the screen). - Not being able to quickly find objects in a pile (for example in a full drawer). - Not being able to quickly recognize a face in a crowd. Or, abnormally slow in identifying optotypes during standard ophthalmological examination as assessed by the optometrist/ophthalmologist.
Exclusion criteria
Exclusion criteria: • Any visual field defect in central 30* with statistical significance of more than 0,95, determined with Humphrey perimetry • Ocular surgery other than uneventful cataract surgery, within 3 months before inclusion to our study • Diagnosis of congenital or acquired optic nerve head pathology. • Diagnosis of manifest glaucoma with defects in the visual field. • Diagnosis of a neurodegenerative disorder or high-energy brain trauma.;Patients: Only for mERG: • Presence of contraindications reported by the participant for tropicamide and phenylephrine • Pregnancy or breast feeding • Hypersensitivity to oxybuprocain;Only for MRI and MEG sessions: • Exclusion criteria determined by the Donders Centre for Cognitive Neuroimaging regarding safety and/or signal interference.;Controls: • Presence of contraindications reported by the participant for tropicamide and phenylephrine • Pregnancy or breast feeding • Exclusion criteria determined by the Donders Centre for Cognitive Neuroimaging regarding safety and/or signal interference. • Hypersensitivity to oxybuprocain
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| • Electrophysiological responses of the retina and the cortex to visual stimuli. • Optical responses of the photoreceptors to visual stimuli. • Performance on computer-based tasks testing central vision, visual attention and motion detection. • Electrophysiological and haemodynamic neural responses of the brain to visual stimuli. | — |
Secondary
| Measure | Time frame |
|---|---|
| Diagnostic value of the speed-acuity to discriminate between patients and controls. Auditory processing speed using a computer-based task in order to exclude the possibility that processing speed in general is disrupted in SV rather than specifically in the visual modality. | — |
Countries
Netherlands
Outcome results
None listed