microscopic bowel inflammation microscopic colitis
Conditions
Interventions
None listed
Sponsors
Medisch Universitair Ziekenhuis Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: In general: aged between 50-75 years, no current use of NSAIDs, PPIs or SSRIs. * For patients in remission: positive diagnosis of microscopic, in remission under medication * For patients with active disease: positive diagnosis of microscopic, collagenous or lymphocytic colitis; confirmed active disease due to relapse, no recent treatment for MC * For healthy controls: no prior positive diagnosis of microscopic, collagenous or lymphocytic colitis.
Exclusion criteria
Exclusion criteria: - Age below 18 years at the time of diagnosis - Use of anticoagulants or immunosuppressive drugs - Severe co-morbidities (including cardiopulmonary disease, portal hypertension, collagen diseases, morbid obesity, coagulation disorders and any co-morbidity hindering an endoscopic procedure) - A previous history of any type of chronic colitis (other than MC), irritable bowel syndrome, colon carcinoma or (partial) colectomy - A recent (last year) diagnosis of infectious diarrhea or radiation proctitis. - Use of medication known for influencing intestinal permeability - Excessive alcohol usage (>20 standard units per week) - Not capable of signing an informed consent - Defaecation diary is not matching the predefined stool frequency for the designated patient group (active, remission, control)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary study outcome is the difference in colon permeability (transpeithelial electrical resistance and FITC-permeation) caused by administration of risk medication between the three groups (MC active, MC remission, MC control) | — |
Secondary
| Measure | Time frame |
|---|---|
| n.a. | — |
Countries
Netherlands
Outcome results
None listed