high blood pressure pulmonary artery Idiopathic/primary pulmonary arterial hypertension
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Groningen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Primary study group: - Patients who are on the waiting list for double-LTX, in our institution, for pulmonary arterial hypertension - Eligible for CMR imaging - No claustrophobia - No pacemaker, ICD, etc. - Informed consent;Control group: - Patients who are on the waiting list for double-LTX, in our institution. - Echocardiographic evaluation including an estimation of RV peak pressure,
Exclusion criteria
Exclusion criteria: - Inability to comply with primary endpoint measures. - Body mass index >40 kg/m2. - Pregnant patients will not be included, they may be included >3 months after pregnancy. - Patients with age
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Right ventricular remodeling measured on cardiac magnetic resonance (CMR) imaging after LTX will be investigated in terms of: 1) RV mass, trabecularisation and extracellular matrix composition; 2) geometry and septal configuration; 3) radial, circumferential and longitudinal deformation. Left ventricular remodeling comprises function, geometry and mass. | — |
Secondary
| Measure | Time frame |
|---|---|
| Functional parameters on echocardiography, disease specific electrophysiological findings on electrocardiography (ECG) and N-terminal probrain natriuretic peptide (NT pro-BNP) level. | — |
Countries
Netherlands
Outcome results
None listed