Skin Fibroblasts for Cholesterol Research

Skin Fibroblasts for Cholesterol Research - Skin Fibroblasts for Cholesterol Research

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON41130

Enrollment

100

Registered

2015-01-21

Start date

2015-06-08

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cholesterol metabolism lipid disorder

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Patients with extreme tail LDL-C, HDL-C or TG levels, defined as >95% or

Exclusion criteria

Exclusion criteria: Age

Design outcomes

Primary

Measure	Time frame
In human skin fibroblasts we study: - Cholesterol uptake. (LDL binding and uptake assays) - Receptor trafficking for receptors involved in cholesterol metabolism (LDL-receptor, ABCA1 and ABCG1). - Cholesterol efflux from the cells.	—

Countries

Netherlands

Outcome results