cognitive performance mental health
Conditions
Interventions
Elderly participants receive three doses (100, 150 and 200 mg/kg bodyweight) of
tyrosine and younger participants receive one dose (150 mg/kg body weight) of
tyrosine. Tyrosine will be mixed with yo
Sponsors
Wageningen Universiteit
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: • Aged 18-35 years or aged 60-75 years • Normal and stable weight (BMI 18.5-25 kg/m2 and weight 50-95 kg) • Willing to abstain from blood donation during the study • Dutch-speaking • Non-smoking • Normal or corrected-to-normal vision
Exclusion criteria
Exclusion criteria: • Thyroid problems, such as hyperthyroidism, hypothyroidism, thyroid cancer • Using medication that can interfere with tyrosine*s action; monoamine oxidase inhibitors and other antidepressants, sympathomimetic amines, and opioids • Following a low-protein diet as prescribed by a dietician or physician • Parkinson*s Disease • Depression • Use of tyrosine supplements • Being allergic or having a dislike to the product carrier (banana-flavored yoghurt) • Bad venous access, as judged by the research nurse • Mini Mental State Examination (MMSE) score
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary study parameter is tyrosine plasma concentration at T0, T90, T120, T150, T180, T210 and T240. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary study parameter is performance on the n-back working memory task measured by accuracy (total number of hits) and reaction time (ms). | — |
Countries
Netherlands
Outcome results
None listed