PRevention of knee Osteoarthritis in Overweight Females (PROOF); long-term follow-up

PRevention of knee Osteoarthritis in Overweight Females (PROOF); long-term follow-up - PROOF study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON41125

Enrollment

330

Registered

2014-08-20

Start date

2014-09-01

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

knee osteoarthritis wear and tear

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: 1) Was participant in original trial. 2) Gave informed consent to be contacted for long-term follow-up at final measurements of the original trial.

Exclusion criteria

Exclusion criteria: No criteria excluding individuals who fulfill the inclusion criteria. Subjects with contra-indications for MRI will only be excluded for MRI measurements and subjects with bi-lateral total knee replacement will only be excluded for MRI and radiography.

Design outcomes

Primary

Measure	Time frame
The primary outcome measure is the incidence of clinical knee osteoarthritis according to the 'clinical and radiologic ACR-criteria'	—

Secondary

Measure	Time frame
The secondary outcome measures are: - incidence of radiologic knee osteoarthritis (K&L >= 2) - incidence of joint space narrowing (JSN >= 1.0 mm) - progression of MRI features of knee osteoarthritis (MOAKS features) - WOMAC pain - WOMAC function - Quality of life - degenerative biomarkers in blood/urine	—

Countries

Netherlands

Outcome results