endothelial function Vascular function
Conditions
Interventions
Following baseline measurements, participants will be asked to consume 70g of
cholclate and two capsules.
The chocolates capsules will vary in epicatechin content.
Combination 1: high flavonoid choc
Sponsors
Wageningen Universiteit
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Age between 40 and 80 years - BMI > 20 and
Exclusion criteria
Exclusion criteria: • Body mass index >30 or = 3 glasses/d • Reported intense sporting activities > 10 h/w • Weight loss or weight gain of 5 kg or more during the last 2 months • Smokers • Vegetarians • Problems with consuming the supplements or following the study guidelines • Recent blood donation (i.e. 1 month) prior to the study and/or planned donation during and shortly after the study period • Not agreeing to be informed about unexpected and medically relevant personal test-results, or not agreeing that their general practitioner will be informed about these results • Participation in another biomedical trial less than 2 months before the start of the study or at the same time • No signed informed consent form • Unable to comply with the study procedure (e.g. holidays, urine collection, blood sampling)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome is the acute response in Flow-Mediated Dilation (FMD) as a marker of vascular function. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary outcomes are: - plasma and urine epicatechin concentrations - pulse wave analysis - plasma nitric oxide and endothelin-1 concentrations | — |
Countries
Netherlands
Outcome results
None listed