Melatonin rhythm in older ICU patients with and without delirium

Melatonin rhythm in older ICU patients with and without delirium - Melatonin rhythm in older ICU patients

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON41099

Enrollment

142

Registered

2014-04-15

Start date

2014-10-01

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

acute confusial state delirium

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Age 60 years or above - Patients or their legal representative must be able to give informed consent - Inclusion directly after ICU admission, but at least within 24 hours of admission - Expected admission to the ICU for longer than one day - Medical or surgical reason for admission to the ICU

Exclusion criteria

Exclusion criteria: - Stroke as the reason for hospital admission - Chronic use of antidepressants or antipsychotics before ICU admission - Use of melatonin before or during hospital admission - Dialysis before admission - History of diagnosed dementia - Absence of arterial or central venous catheter

Design outcomes

Primary

Measure	Time frame
The primary endpoint will be the differences in the maximal concentration of melatonin in critically ill elderly with or without delirium during ICU admission.	—

Secondary

Measure	Time frame
Secondary outcomes will be the (differences in) melatonin secretion pattern, defined as the percentage peak melatonin concentration that are secreted between 23pm and 6am, in older persons with and without delirium for seven consecutive days. Also, we will study if sepsis, mechanical ventilation, renal failure or (nor) adrenergic stimulation influence melatonin secretion patterns in patients admitted to the ICU.	—

Measure

Time frame

Secondary outcomes will be the (differences in) melatonin secretion pattern, defined as the percentage peak melatonin concentration that are secreted between 23pm and 6am, in older persons with and without delirium for seven consecutive days. Also, we will study if sepsis, mechanical ventilation, renal failure or (nor) adrenergic stimulation influence melatonin secretion patterns in patients admitted to the ICU.

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Countries

Netherlands

Outcome results