adrenal response physical condition
Conditions
Interventions
exercise test
saliva will be colected before and after the 20 meter shuttle run test
VO2max will be detrmined during teh cycle test
Sponsors
Martini Ziekenhuis
Eligibility
Age
2 Years to 11 Years
Inclusion criteria
Inclusion criteria: Group 1: Healthy children boys age 8-12 years prepuberal according to Tanner stage BMI -1.1 to 1.1 SD No limitations to perform exercise test (participates in community sports and/or physcial exercise lessons at school);Group 2: Children with asthma boys age 8-12 years prepuberal according to Tanner stage BMI -1.1 to 1.1 SD stable asthma (no change in maintenance medication and no systemic steroids in previous 3 months) Maintenance dose of inhaled corticosteroids 90% of predicted value) No limitations to perform exercise test (participates in community sports and/or physcial exercise lessons at school);Group 3: children with newly diagnosed asthma boys age 8-12 years prepuberal according to Tanner stage BMI -1.1 to 1.1 SD No use of inhaled corticosteroids and no systemic steroids in previous 6 months Normal pulmonary function (FEV1 > 90% of predicted value) No limitations to perform exercise test (participates in community sports and/or physcial exercise lessons at school)
Exclusion criteria
Exclusion criteria: No informed consent If exercise test are contraindicated due to physical condition or comorbidity as judged by treating physisian If the child does not cooperate or does not want to continue the tests Use of medication which may potentially affect steroid metabolism
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Salivary cortisol respons and VO2max of the children with asthma compared to the healthy children . | — |
Secondary
| Measure | Time frame |
|---|---|
| Correlation between salivary cortisol respons and VO2max | — |
Countries
Netherlands
Outcome results
None listed