not applicable
Conditions
Interventions
None listed
Sponsors
TNO
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1.Healthy female participants aged 20-45 years inclusive; 2.BMI: 20-30 kg/m2 inclusive; 3.Written consent regarding participation after full information regarding all details of the study; 4.Normal Dutch eating habits (consuming mostly three main meals per day; used to eat bread for lunch);
Exclusion criteria
Exclusion criteria: 1.Pregnancy; 2.On-going or recent treatment for diabetes, hypertension, coronary heart disease, psychiatric conditions, inflammatory chronic disease - rheumatoid arthritis, Crohn Disease, ulcerous colitis, chronic constipation, eating disorders, or any disease condition which interferes with ADME of the investigational product; 3.Reported postmenopausal; 4.Having menstruation problems, e.g. PCOS; 5.Reported to be on a slimming diet or other dietary treatment (currently or during last two months, like vegetarian diet, lactose restricted diet etc.); 6.Aversion towards products (yoghurt) provided in the study; 7.On-going use of any slimming preparations; 8.Any kind of dysfunction of digestive tract, food allergy, chronic constipation, recent/actual gastroenteritis; 9.Restrained eaters 10.Participants consuming more than 23 g of dietary fiber per day 11.Smoker in the last 3 months; 12.Heavy coffee drinkers (more than 6 cups a day); 13.High level of physical activity 14.Heavy alcohol consumers
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Energy, macronutrient and fiber intake from ad libitum lunch; Appetite/satiety variables measured by VAS questionnaires: hunger, satisfaction, fullness, prospective food consumption, and desire to eat, Mood and well-being; Satiety hormones: CCK, ghrelin, PYY and GLP-1 Glucose and insulin Stomach emptying rate Energy intake from diaries | — |
Secondary
| Measure | Time frame |
|---|---|
| see previous section | — |
Countries
Netherlands
Outcome results
None listed