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The association between loss of gut wall integrity as measured by ZOnulin and hepatic ischaemia as measured by NIRS and Biliary Atresia development

The association between loss of gut wall integrity as measured by ZOnulin and hepatic ischaemia as measured by NIRS and Biliary Atresia development - ZOBANIRS

Status
Unknown
Phases
Unknown
Study type
Observational
Source
NL-OMON
Registry ID
NL-OMON41086
Enrollment
20
Registered
2014-10-28
Start date
Unknown
Completion date
Unknown
Last updated
2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

bile duct atresia biliary atresia

Interventions

None listed

Sponsors

Universitair Medisch Centrum Groningen
Lead Sponsor

Eligibility

Age
2 Years to 11 Years

Inclusion criteria

Inclusion criteria: Suspected biliary atresia, as controls patients with pyloric stenosis (same age group but without liver disease)

Exclusion criteria

Exclusion criteria: No biliary atresia during surgery, other gastro-intestinal diseases (except pyloric hypertrophy)

Design outcomes

Primary

MeasureTime frame
Serum Zonulin levels and liver NIRS—

Secondary

MeasureTime frame
Other serum tight junction and translocation markers (e.g. Claudin 3 and/or LBP) Histologic assessment of the tight junction complex in the small bowel, VEGF-A expression in the liver—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)