preventie/metabole flexibiliteit na
Conditions
Interventions
Each person will consume a high or low dairy diet for 6 weeks in a cross-over
design (with a wash-out period in between of 4 weeks). Subjects are tested
after each 6-week intervention period. Two ch
an OGTT (including 2H-labeled glucose infusion to
study glucose metabolism/kinetics and insulin sensitivity) as well as a
subsequent fasting challenge. During both tests, respiratory gas exchange wi
Sponsors
Universitair Medisch Centrum Groningen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1. Healthy male or postmenopausal female 2. Middle-aged: between 45 and 65 yrs of age 3. BMI >= 25 to
Exclusion criteria
Exclusion criteria: 1. Diabetes mellitus (based on fasting glucose and HbA1c-values at screening) 2. Clinically relevant abnormalities in blood lipids (total cholesterol > 8 mmol/L, triglycerides > 6 mmol/L, LDL >5,7 mmol/L) at screening 3. Clinically relevant abnormalities in hematology (ao Hb
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| As an indicator of metabolic flexibility the change in RQ (ΔRQ) during each challenge test (OGTT and subsequent fasting) will be measured on the test day. This parameter relates to the change in substrate oxidation (fatty acids vs. glucose). | — |
Secondary
| Measure | Time frame |
|---|---|
| In addition, postprandial glucose kinetics and insulin sensitivity will be determined. | — |
Countries
Netherlands
Outcome results
None listed