The clinical effect of mTOR inhibition on lipid metabolism in renal transplant recipients

The clinical effect of mTOR inhibition on lipid metabolism in renal transplant recipients - The clinical effect of mTOR inhibition on lipid metabolism

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON41053

Enrollment

Registered

2014-10-27

Start date

2014-09-01

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

transplantatie onderzoek dyslipidemia

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Renal transplant recipients from Leiden who will participate after informed consent in the global TRANSFORM Study (P13-233).

Exclusion criteria

Exclusion criteria: Any standard contraindications for MRI or 1H-MRS (i.a. claustrophobia, metal parts, etc)

Design outcomes

Primary

Measure	Time frame
- Fasting serum lipid profile (LDLc, HDLc, TG, Total Cholesterol, lipoprotein profile) - Proton-magnetic resonance spectroscopy (1H-MRS) assessed ectopic lipid accumulation in liver (primary) and heart (secondary). - Non-contrast MR assessed visceral and subcutaneous adipose tissue (VAT, SAT) - Non-contrast MR assessed cardiovascular function.	—

Countries

Netherlands

Outcome results