Prevention of rejection after transplantation by donor-specific suppression immunity with donor exosomes (protocol id: DOBEX)

Prevention of rejection after transplantation by donor-specific suppression immunity with donor exosomes (protocol id: DOBEX) - Prevention of rejection with donor exomes

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON41041

Enrollment

Registered

2014-07-29

Start date

2014-06-01

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

liver grafts

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: The experimental group of patients that undergo liver transplantation in Erasmus MC

Exclusion criteria

Exclusion criteria: Liver transplant recipients who recieve a donor liver of which we do not obtain donor spleen tissue Liver transplant recipients with a low white blood cell count (

Design outcomes

Primary

Measure	Time frame
induction of apoptosis in donor-specific T-cells that response directly to allo-antigen, and induction of anergy (= unresponsiveness to antigenic stimulation) in donor specific T-cells that respond to indirectly presented allo-antigens.	—

Secondary

Measure	Time frame
n.a.	—

Countries

Netherlands

Outcome results