respiratory muscle activity during mechanical ventilation and spontaneous breathing trials

respiratory muscle activity during mechanical ventilation and spontaneous breathing trials - respiratory muscles during mechanical ventilation

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON41031

Enrollment

Registered

2014-07-24

Start date

2014-05-01

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

respiratory failure due to muscle weakness

Interventions

Diagnostic interventions: Surface Electromyography (sEMG) is a non-invasive technique used to measure muscle activity. With sEMG signals of the respiratory muscles (diaphragm, intercostal and scalen

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: age >18 yr. respiratory failure due to severe weakness of the respiratory muscles in absence of pulmonary disease (e.g. myasthenia, cervical spine injury) respiratory failue de to severe weakness of the respiratory muscles with concomitant lung pathology (e.g. end stage ARDS, COPD and lung transplant) ability to breathe spontaneously for 10 minutes written informed consent

Exclusion criteria

Exclusion criteria: Reduced respiratory drive and inability to breath spontaneously without ventilator support for > 10 minutes Hemodynamic instability defined as blood pressure below 100 / 60 mmHg Air leaks by cannula or chest tubes: defined as leaks above 1 liter per minute Severe hypoxemia defined as paO2 below 8 kPa Esophagus or neck surgery

Design outcomes

Primary

Measure	Time frame
The difference in activity of the respiratory muscles between the low and high assist level in mechanically ventilated critically ill patients admitted to the intensive care unit.	—

Secondary

Measure	Time frame
The difference in activity of the respiratory muscles between mechanical ventilation and spontaneous breathing in critically ill patients admitted to the intensive care uni	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)