ontwikkelingsstoornissen NEG Tourette's and ADHD
Conditions
Interventions
None listed
Sponsors
Donders Institute of Brain, Cognition and Behavior
Eligibility
Age
2 Years to 11 Years
Inclusion criteria
Inclusion criteria: (1) Aged 8 - 12 years at initial inclusion (2) IQ > 70 (3) Ability to speak and comprehend the native language of the country in which the assessment takes place (4) Caucasian descent (5) Signed informed consent by parents or legal representative (6) DSM-5 diagnosis of Tourette's Disorder or Persistent (chronic) Motor or Vocal tic Disorder (motor tics only) (APA, 2013).
Exclusion criteria
Exclusion criteria: (1) Intellectual disability (IQ
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Structural, diffusion and functional (resting state and task specific) MRI images will be obtained (approx. 60mins). Two neuropsychological tasks will be performed in an fMRI environment (go/no-go and monetary reward anticipation) with another 4 tasks completed outside of the MRI environment (motor inhibition and cognitive flexibility, verbal working memory, motor speed, cognitive flexibility). Phenotyping will be done by semi-structured interview for the Yale Global Tic Severity Scale (YGTSS) and Children*s Yale-Brown Obsessive Compulsive Scale (CY-BOCS). ADHD symptoms will be assessed additionally by Conners questionnaire. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secundary endpoints are (1) genotypes of candidate genes and (2) lab assesments of various proteins in blood plasma. | — |
Countries
Netherlands
Outcome results
None listed