adenocarcinoma of the gastro-esophageal junction Barrett's esophagus
Conditions
Interventions
None listed
Sponsors
Maag-, Darm- en Leverziekten
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: As described earlier, we identified in a collaborative effort (with the Departments of Surgery and Medical Genetics) 20 index patients from families that fulfill the criteria for familial BE or adenocarcinoma of the GEJ. Apart from the retrospectively identified index patient, new index patients identified during this study by the department of Medical Genetics will also be eligible for this study,;The criteria for familial BE or adenocarcinoma of the GEJ: A. Two or more first- or second degree relatives with BE or adenocarcinoma of the GEJ, with at least one diagnosed before the age of 50 B. Three or more first- or second degree relatives with BE or adenocarcinoma of the GEJ, irrespective of age C. One patient with BE or adenocarcinoma of the GEJ
Exclusion criteria
Exclusion criteria: A potential individual who meets any of the following criteria will be excluded from participation in this study: 1) Individuals 75 years old 2) Unable to fill out questionnaire
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Determine the prevalence of BE among first degree relatives of index patients of families that fulfil criteria for familial BE/adenocarcinoma of the GEJ Determine the number and type of (pre) malignant lesions in first degree relatives of index patients of families that fulfil criteria for familial BE/adenocarcinoma of the GEJ | — |
Countries
Netherlands
Outcome results
None listed