type 2 diabetes
Conditions
Interventions
Subjects will reduce their daily caloric intake with 50% for 4 weeks. Subjects
will be randomized into either a hypocaloric diet group where 15% of total kcal
have to be consumed with breakfast, 35%
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Male - BMI * 30kg/m2 - Age 50-80 years - At least 3 out of 5 metabolic syndrome criteria: fasting plasma glucose * 5.6 mmol/l, triglycerides * 1.7 mmol/l, waist-circumference > 102 cm, HDL-cholesterol 1.04 mmol/l, blood pressure * 130/85 mmHg - Stable weight three months prior to study inclusion
Exclusion criteria
Exclusion criteria: - Use of any medication except for those related to treatment of components of the metabolic syndrome (excluding insulin, oral glucose lowering drugs, beta-blockers) - Any actual medical condition except for treated hypothyroidism and the metabolic syndrome - History of any psychiatric disorder - Shift work - Irregular sleep pattern - Intensive sports (>3/week) - Restrained eaters - History of eating disorders (anorexia, binge eating, bulimia) - Smoking, XTC, amphetamine or cocaine abuse - Alcohol abuse (>3/day) - Contraindication MRI - Lactose intolerance
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| * Insulin sensitivity: 2-step hyperinsulinemic euglycemic clamp with stable glucose isotope tracer * Serotonin transporter availability : [123I]FP-CIT SPECT scan * Serotonergic activity: pharmacological MRI using citalopram | — |
Secondary
| Measure | Time frame |
|---|---|
| * Motivation and impulse control: functional MRI * Abdominal and liver fat: magnetic resonance sprectroscopy (MRS) * Circulating hormones and substrates: blood drawing * Sleep duration: Actiwatch * Sympathetic and parasympathetic activity: heart rate variability * Feeding behaviour: questionnaires | — |
Countries
Netherlands
Outcome results
None listed