Abnormal immune system in Down syndrome: allergic sensitization and hepatitis B vaccination status 2 - blood sample

Abnormal immune system in Down syndrome: allergic sensitization and hepatitis B vaccination status 2 - blood sample - All-HBV-DS2 - blood sample

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON40983

Enrollment

580

Registered

2014-04-07

Start date

2014-03-01

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

downsyndroom Down syndrome trisomy 21

Interventions

None listed

Eligibility

Age

2 Years to 99 Years

Inclusion criteria

Inclusion criteria: Down syndrome; 2 years of age or older; planned venepuncture.

Exclusion criteria

Exclusion criteria: No informed consent; participation in the All-HBV-DS1-leftover serum study (study on the same subject, but leftover serum is used for the tests). In each participant the tests will only be performed once.

Design outcomes

Primary

Measure	Time frame
Percentage of people with at least one allergen specific IgE with a concentration of >= 0,35 kU/l; the percentage of people with a protective titer against HBV (anti-HBs-titer >=10 IE/l).	—

Secondary

Measure	Time frame
The concentration of total IgE, the concentration of specific IgE*s in the inhalation antigen and food antigen mix, the relation between age and sensitization and between sensitization, allergy related symptoms and the performance of diagnostic tests and/or treatments and the percentage of people with elevated total IgE. The level of the HBV titer (anti-HbS).	—

Countries

Netherlands

Outcome results