Late LTP-like plasticity effects of tDCS in chronic stroke patients

Late LTP-like plasticity effects of tDCS in chronic stroke patients - tDCS-LPCS

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON40977

Enrollment

Registered

2014-07-24

Start date

2014-09-01

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cerebrovascular accident Stroke

Interventions

tDCS will be administered with a CE-certified stimulator (DC-Stimulator Plus, neuroConn, Germany

CE 0118). The different stimulation protocols are: 30 seconds stimulation at t=0 and t=34 minutes (sham), 20 min. anodal bihemispheric stimulation and 30 seconds of sham stimulation at t=36 minutes

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Chronic (> 6 months) stroke patient Aged 18-80 years Motor deficit in the upper limb due to the stroke

Exclusion criteria

Exclusion criteria: Being unable to perform the task or to understand the instructions/ apraxia Presence of intracranial metal Epilepsy Alcoholism Cognitive impairment, or psychiatric disorder History of psychiatric disorders Taking acute or chronic psychoactive drugs Absence of recordable MEPs after TMS Hemineglect

Design outcomes

Primary

Measure	Time frame
The main objective of the study is to determine the effect of late plasticity tDCS on skill learning 24 hours later. As a motor learning paradigm, we will use a circuit tracking task which chronic stroke patients perform better if tDCS is applied concurrently. During this task, patients have to trace a cursor over a circuit as fast and accurate as possible by moving a computer mouse. Skill will be quantified by calculating a combined speed/ accuracy score and compared between sham, conventional unpaired tDCS, conventional paired tDCS and late LTP-like plasticity tDCS groups.	—

Measure

Time frame

The main objective of the study is to determine the effect of late plasticity tDCS on skill learning 24 hours later. As a motor learning paradigm, we will use a circuit tracking task which chronic stroke patients perform better if tDCS is applied concurrently. During this task, patients have to trace a cursor over a circuit as fast and accurate as possible by moving a computer mouse. Skill will be quantified by calculating a combined speed/ accuracy score and compared between sham, conventional unpaired tDCS, conventional paired tDCS and late LTP-like plasticity tDCS groups.

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Secondary

Measure	Time frame
• To compare excitability changes following late plasticity tDCS in stroke patients with concurrent tDCS stimulation and sham stimulation • To identify improvement in arm/ hand functions unrelated to skill learning and generalization of skill learning to a new circuit with the same arm/hand. • To determine the main effect of several polymorphisms known to be involved in plasticity on skill learning. • To determine if skill learning with the unaffected arm correlates with skill learning with the affected arm.	—

Measure

Time frame

• To compare excitability changes following late plasticity tDCS in stroke patients with concurrent tDCS stimulation and sham stimulation • To identify improvement in arm/ hand functions unrelated to skill learning and generalization of skill learning to a new circuit with the same arm/hand. • To determine the main effect of several polymorphisms known to be involved in plasticity on skill learning. • To determine if skill learning with the unaffected arm correlates with skill learning with the affected arm.

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Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)