Characterisation of neurotransmitter network dysfunction in MRI-negative localisation-related epilepsy

Characterisation of neurotransmitter network dysfunction in MRI-negative localisation-related epilepsy - Neurotransmitter network dysfunction in epilepsy

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON40961

Enrollment

Registered

2014-11-03

Start date

2014-11-21

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Epilepsy falling sickness

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: General: Subjects must be older than 18 years and able to give informed consent. ;Epilepsy patients: - Diagnosed with cryptogenic localization-related epilepsy with an epileptic focus in the frontal or temporal lobe (using EEG) - Seizure frequency below 13/year. - No changes in anti-epileptic drugs (medication or dose) in the last 6 months.

Exclusion criteria

Exclusion criteria: General: - MRI visible lesions, as seen on the clinical 3T scans - All absolute or relative contraindications for MR scanning. - A medical history with cerebral diseases (other than epilepsy), vascular problems, diabetes mellitus, hypertension and/or cerebral surgery.

Design outcomes

Primary

Measure	Time frame
The primary study parameters are the neurotransmitter network properties of MRI-negative localization-related epilepsy patients compared to those of healthy subjects.	—

Secondary

Measure	Time frame
Secondary study parameters are functional and structural network properties and the relation between these and the neurotransmitter network properties of MRI-negative localisation-related epilepsy patients.	—

Countries

Netherlands

Outcome results