Study on the effects of hyperoxemia on hemodynamic parameters and cardiac function

Study on the effects of hyperoxemia on hemodynamic parameters and cardiac function - Oxflow

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON40934

Enrollment

Registered

2014-09-09

Start date

2014-09-22

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hemodynamic changes microcirculation

Interventions

The measurements will be carried out in hemodynamically stable patients after cardiac surgery 1. Increase of supplemental oxygen (FiO2) to 90% 2. Mandatory inspiratory hold maneuvers. Four 12-sec in

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Scheduled for ventilation and sedation at the ICU after elective coronary artery bypass grafting - Aged 18-65 years - Being able to give written informed consent prior to surgery

Exclusion criteria

Exclusion criteria: - Pregnancy - Hemodynamic instability with a mean arterial pressure (MAP) 18 mm Hg and / or dependence on moderate to high dosages of inotropic drugs after admittance to the ICU (noradrenalin > 0.1 ug/kg/min or dobutamin > 5 ug/kg/min or adrenalin at any dose or milrinone > 0.6 ug/kg/min - Severe arrhythmias - Intra-cardiac shunts - Symptomatic peripheral vascular disease - Symptomatic pulmonary disease - Clinically significant aortic aneurysm - Significant valvular regurgitation - Prior diagnosis of aberrant cardiovascular anatomy

Design outcomes

Primary

Measure	Time frame
Cardiac Output Blood flow arteria cerebri media rechts Microcirculation	—

Secondary

Measure	Time frame
Mean arterial pressure Stroke Volume (Variation) Pulse Pressure (Variation) Systemic Vascular Resistance Heart rate	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)