Peripartum cardiomyopathy pregnancy-related heart failure
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Groningen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Patients: • Ages from 18 and older. • Diagnosis PPCM according to the revised European Society of Cardiology guidelines 2012. • Participation of healthy sister (or female cousin) that has been pregnant at least once without diagnosis of PPCM. • Possibility of adequate communication. • Informed consent is obtained.;Controls: • Ages from 18 and older. • Sister or (female) first cousin of patient. • Generally in good health. • Has been pregnant without cardiac complications. • Possibility of adequate communication. • Informed consent is obtained.
Exclusion criteria
Exclusion criteria: Patients: • Other etiology of heart failure other than PPCM. • A healthy sister (or female cousin) cannot be included, for any reason. • Severe complications during pregnancy (aside from PPCM). • Extensive skin disorder precluding a biopsy from unaffected skin area. • Known allergy for local anesthetics. • Informed consent can, for whatever reason, not be obtained.;Controls: • Has never been pregnant. • Severe complications during pregnancy (including cardiac complications) • Extensive skin disorder precluding a biopsy from unaffected skin area. • Known allergy for local anesthetics. • Informed consent can, for whatever reason, not be obtained.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - IPS cells can be generated from skin fibroblasts of test subjects and can be differentiated into cardiomyocytes. - Cardiomyocytes derived from test subjects via IPS reprogramming show differences in expression profiles and in responses to stress in comparison to those of healthy controls. | — |
Countries
Netherlands
Outcome results
None listed