polyfarmacie, anticholinerge- en sedatieve bijwerkingen polypharmacy use of more than 5 medications at the same time
Conditions
Interventions
A structured 5-step multidisciplinary medication review (STRIP method) as
described in the multidisciplinary guidelines by the Nederlands Huisartsen
Genootschap (2013) including the objective to red
Sponsors
Rijksuniversiteit Groningen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Patient with age >= 65 years, use of >= 5 medications, DBI >= 1 and written informed consent.
Exclusion criteria
Exclusion criteria: Pharmacy: Only community pharmacists who are working in close collaboration with the general practitioner will be included. ;Patients: Patients with palliative care only and a limited life expectancy (
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome is the difference in proportion of patients having a decrease of the DBI >=0.5 between the intervention and control group at follow up. After a medication review it is expected that the proportion of patients with a decrease of DBI >=0.5 in the intervention group is significantly higher in comparison to the control group. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes are: a) Anticholinergic side effects, measured by the UKU side effect rating scale b) Sedating side effects, measured by a validated patient-reported adverse drug event questionnaire c) Risk of falls, measured by patients reports fall incidents and the *Up & Go* test d) Cognitive function, measured by the Seven Minute Screen, the Trailmaking Test A & B and the Digit Symbol Coding Test e) Loss of self-reliance, measured by the Groningen Activiteiten Restrictie Schaal f) Quality of life: measured with the EQ-5D-3L questionnaire g) Hospitalization h) Mortality i) Proportion of patients having a DBI | — |
Countries
Netherlands
Outcome results
None listed