Immunological effects of BCG on vaccination with the yellow fever vaccine.

Immunological effects of BCG on vaccination with the yellow fever vaccine. - Immunological effects of BCG on vaccination with the yellow fever vaccine.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON40902

Enrollment

Registered

2014-12-09

Start date

2015-02-12

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Immune modulation modulation of the immune system

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Healthy 18-55 years old

Exclusion criteria

Exclusion criteria: Exposed to TBC, BCG or yellow fever (vaccine), use of mediation

Design outcomes

Primary

Measure	Time frame
According to the objectives: 1) Increase of in vitro cytokine production of PBMCs after stimulation with different pathogens compared to before yellow fever vaccination. (only placebo group) 2) Yellow fever antibody titers, Th-immune responses, and proinflammatory cytokine production in BCG versus placebo vaccinated volunteers. 3) The rate of clearance of the circulating yellow fever vaccine virus in BCG- versus placebo-vaccinated volunteers.	—

Measure

Time frame

According to the objectives: 1) Increase of in vitro cytokine production of PBMCs after stimulation with different pathogens compared to before yellow fever vaccination. (only placebo group) 2) Yellow fever antibody titers, Th-immune responses, and proinflammatory cytokine production in BCG versus placebo vaccinated volunteers. 3) The rate of clearance of the circulating yellow fever vaccine virus in BCG- versus placebo-vaccinated volunteers.

—

Secondary

Measure	Time frame
n.v.t.	—

Countries

Netherlands

Outcome results