diseas of the heart and vessels
Conditions
Interventions
Tea ingestion
Sponsors
Unilever
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Males and post-menopausal (> 1 years) females - Aged >45 and
Exclusion criteria
Exclusion criteria: - Regular performance of strenuous exercise/sport of > 2 hours per week - Current smoker or has stopped smoking less than 6 months before start of study - Self reported alcohol intake of >21 units/week) - Established cardiovascular disease - Diabetes mellitus - Blood pressure > 160/100 mmHg - Subjects taking any medication that might affect endothelial function (e.g. but not limited to beta-blockers, ACE-inhibitors, statins, anti-coagulants, anti-depressants, hormone replacement therapy) will be excluded from the study. Subjects who are on stable medication for which there is no indication of an effect on endothelial function, will be allowed to participate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Forearm resistance artery blood flow (measured using venous occlusion plethysmography) in response to incremental doses of acetylcholine (endothelium-dependent dilator; primary parameter), sodium nitroprusside (endothelium-independent dilator; secondary parameter) and L-NMMA (nitric oxide synthase blocker; secondary parameter). | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood pressure | — |
Countries
Netherlands
Outcome results
None listed